文献：

The Efficacy of 18F-FDG PET/CT and Superparamagnetic Nanoferric Oxide MRI in the Diagnosis of Lung Cancer and the Value of 18F-FDG PET/CT in the Prediction of Lymph Node Metastasis

文献链接：

https://pubmed.ncbi.nlm.nih.gov/34552658/

作者：

Lan Yao, Mingfei Zuo, Na Zhang,Tian Bai,and Qicheng Huang

相关产品：

超顺磁性氧化铁纳米 SPION

原文摘要：In China, lung cancer is one of the leading causes of death among residents. Early diagnosis is of great significance for early interventional treatment and prolonging survival. PET/CT uses positron radiopharmaceuticals to observe the physiological and biochemical changes of the drug and its metabolites in the body and finally diagnoses the disease. 18F-FDG is a commonly used imaging agent, but its short isotopic half-life limits clinical high-throughput testing. This study retrospectively analyzed the imaging material of 100 lung cancer patients pathologically confirmed. Patients with lymph node metastasis were classified into the LM group (n = 30 cases), and those with no lymph node metastasis were classified into the NLM group (n = 70 cases). The results showed that MRI of superparamagnetic nanoferric oxide was better than diagnosis of lung cancer by the 18F-FDG PET/CT and had a high predictive power for lymph node metastasis. These turned out to be high-value lung cancer diagnosis of superparamagnetic nanoferric oxide MRI and high-capacity lymph node metastasis prediction of 18F-FDG PET/CT, which were worthy of implementation.

18F-FDG是一种常用的显像剂，它可以跟踪肺tumor中葡萄糖的代谢过程，检测肺tumor的活性和位置，最终对lung cancer进行有效的鉴别诊断。虽然这种诊断方法具有高度敏感和可量化，但其同位素半衰期较短，限制了高通量检测。超顺磁性氧化铁纳米颗粒（SPION）具有表面积大、生物相容性低、强制力低的特点，为核磁共振成像创造了条件。SPION是一种纳米级的铁磁分子，它可以均匀地分散在基载体液体中。在外加磁场的作用下，SPION可以沿着磁场线形成不同的形状。超顺磁性纳米氧化铁的MRI优于18F-FDG PET/CT诊断lung cancer，对lymph结转移具有较高的预测能力。

18F-FDG PET/CT和超顺磁纳米氧化铁氮MRI对lung cancer评估的敏感性分别为81.97%和95.08%，特异性分别为76.92%和97.44%。相比之下，超顺磁性纳米氧化铁氮MRI检测的灵敏度和特异性明显提高。这说明超顺磁性纳米氧化铁的MRI在lung cancer的应用中准确和有效。此外，还采用超顺磁性纳米氧化铁粒子作为超顺磁性纳米氧化铁磁共振成像的造影剂。SPION结合了超顺磁性和纳米级的特性。它不仅具有超顺磁性，而且可以与人体组织兼容。用于lung cancer的SPION颗粒大小一般为50~100 nm；由于其与人网状内皮系统的高亲和力，它很容易被正常肺组织上的网状内皮细胞吞噬。

图：SPION的电镜图

结论：SPION含有超顺磁性氧化铁纳米颗粒，是MRI检查的组成部分。比较18F-FDG PET/CT超顺磁纳米氧化铁MRI能更好地用于lung cancer，18F-FDG PET/CT对lymph结转移有较高的预测作用。纳米氧化铁CT与超顺磁性FDG PET/CT在lung cancer中具有较高的价值，也可以很好地预测lymph结转移。