文献：near-infrared nanoparticles based on indocyanine green-conjugated albumin: a versatile platform for imaging-guided synergistic tumor chemo phototherapy with temperature-responsive drug release

文献链接：https://www.cqvip.com/doc/journal/2713118119

作者：Ma Yuxin; Liu Xiaohua; Ma Qianli; Liu Yizhi

相关产品：Sulfo ICG-NHS ester 水溶性吲哚菁绿-活性酯

原文摘要：

Background(#br)The aim of this study was to develop a multifunctional theranostic agent based on BSA nanoparticles (NPs), which loaded artemisinin (ART) and co-conjugated with indocyanine green (ICG) and arginine-glycine-aspartic acid (RGD) peptide (RGD-indocyanine green-Bovine Serum Albumin-artemisinin [IBA] NPs).(#br)Materials and methods(#br)The physicochemical parameters of RGD-IBA NPs were character-ized in terms of the particle size, zeta potential, morphology, entrapment efficiency, drug loading, in vitro release behavior, photothermal and photodynamic effect, and in vitro anticancer ability. In vivo fluorescence and thermal imaging as well as antitumor studies were also evaluated.(#br)Results(#br)The tumor chemotherapeutic effects of ART and the ability of fluorescence imaging, hyperthermia generation and reactive oxygen species production of ICG and tumor-targeting RGD were integrated to achieve RGD-IBA NPs for imaging-guided tumor-targeted chemotherapy/photothermal/photodynamic therapy (chemo-phototherapy). The RGD-IBA NPs showed enhanced physiological stability and photo-stability compared with free ART and ICG. In addition, they were temperature-responsive; their sizes increased with increasing temperature between 25°C and 55°C, thereby leading to drug release upon the irradiation with near infrared (NIR) laser. In vivo fluorescence images of tumor-bearing mice showed that the RGD-IBA NPs could highly and passively reach the targeted tumor region with maximum accumulation at 24 hours post-intravenous injection. The in vitro and in vivo results demonstrated that the RGD-IBA NPs not only have good biocompatibility, but also are highly efficient tumor synergistic chemo-phototherapeutic agents.(#br)Conclusion(#br)Through this study, it was found that RGD-IBA NPs could potentially be a very promising tumor theranostic agent.

该文献研究一种基于水溶性ICG-NHS酯（Sulfo ICG-NHS ester）的新型纳米粒子，该纳米粒子由吲哚菁绿（Indocyanine Green, ICG）和白蛋白结合而成。Sulfo ICG-NHS ester能够有效地与白蛋白结合，形成稳定的晚红外纳米粒子。这些纳米粒子在成像指导中展现出应用能力。通过近红外成像技术，能够清晰观察到特定位置和大小，从而定位。

图1：合成和应用原理图。

结论：Sulfo ICG-NHS ester在其对温度响应能力上具有优势。局部温度的提高能够触发化合物（有效物质）的释放，从而实现效果。这种智能化的化合物递送系统降低了对正常组织的损伤风险，减少副作用。