文献：Synergistic photothermal/photodynamic suppression of prostatic carcinoma by

targeted biodegradable MnO2 nanosheets

文献链接：https://www.cqvip.com/doc/journal/2728941773

作者：Zeng, Dewang1Wang, Lei2Tian, Lu1Zhao, Shili1Zhang, Xianfeng3Li, Hongyan

相关产品：cRGD-PEG2000-NH2 cRGD肽-聚乙二醇2000-氨基

原文摘要：The biodegradability and clearance of metal-based nanomaterials have been questioned worldwide, which have greatly limited their clinical translation. Herein, ultrathin manganese dioxide (MnO2) nanosheets with broad near-infrared (NIR) absorption and pH-dependent degradation properties were prepared. After being modified with polyethylene glycol-cyclic arginine-glycineaspartic acid tripeptide (PEG-cRGD), the MnO2 nanosheets were then used as photothermal agent and nanocarrier to encapsulate chlorin e6 (Ce6) for targeted photothermal (PTT) and photodynamic (PDT) of cancer. As expected, the MnO2-PEG-cRGD nanosheets show high Ce6 loading capacity (351 mg/g), superb photothermal conversion performance (37.2%) and excellent colloidal stability. These nanosheets also exhibit pH-dependent and NIR-induced Ce6 release. Furthermore, the MnO2 nanosheets can be degraded by reacting with hydrogen peroxide in the acidic microenvironment, which are able to elevate the oxygen concentration in situ and thus reverses the tumor hypoxia. Thanks to these favorable properties and the cRGD-mediated tumor-targeted ability, the fabricated MnO2-PEG-cRGD/Ce6 nanocomposites can be effectively up taken by alpha-v beta-3 (αvβ3) integrin over-expressed prostatic carcinoma PC3 cells and achieve favorable therapeutic outcomes under a single 660 nm NIR laser, which is also verified by in vitro studies. The biodegradable MnO2-PEG-cRGD/Ce6 nanosheets developed in this work can be a promising nanoplatform for synergetic PTT/PDT cancer therapy.

cRGD-PEG2000-NH2 是一种具有高度靶向性的分子，能够准确地识别并结合prostate cancer细胞表面的特定受体。在该文献研究中，揭示了cRGD-PEG2000-NH2与可生物降解的MnO2纳米片结合，在对抗Prostate cancer的研究中提供了新的策略。

图示1：MnO2-PEG-cRGD/Ce6复合材料作为生物可降解纳米平台的制备示意图。

该文献设计了一种聚合物载体cRGD-PEG2000-NH2，具备良好的生物相容性和靶向性。该载体能够靶向聚集在prostate cancer细胞上，在进入人体后，它能够引导纳米片准确地聚集在病变部位，避免对正常组织造成不必要的损伤。提高了其准确性和安全性。随后与可生物降解的MnO2纳米片共同发挥作用。

图示2：(A)二氧化锰和(B) MnO2-PEG-cRGD纳米片的透射电镜图像。(C)二氧化锰和MnO2-PEG-cRGD纳米片的DLS尺寸分布。二氧化锰纳米片的(D) Mn 2p XPS光谱。(E)二氧化锰、MnO2-PEG-cRGD和MnO2-PEG-cRGD/Ce6（n¼3）的Zeta电位。(F)Ce6、MnO2-PEG-cRGD和MnO2PEGcRGD/Ce6的紫外-可见光谱。

     结论：cRGD-PEG2000-NH2 发挥关键作用。该分子在纳米片表面提供了靶向性，能够有效识别并结合prostate cancer细胞。在光热和光动力Treatment 中，增强效果，减少对正常组织损伤，cRGD修饰的纳米系统在抑制tumor生长和诱导Apoptosis 方面表现出协同作用，提具有效率。